Santee Vacations from MXN$19,089

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to MXN$7,484 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

The Latest Santee Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Hyatt Place Columbia/Harbison
stayAPT Suites Columbia-Irmo Harbison
Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG
Hilton Garden Inn Columbia/Harbison
Holiday Inn Express & Suites Lexington by IHG

Find the Best Santee Vacation Packages

Santee Hotel Deals

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street, Santee, SC
Fully refundableReserve now, pay when you stay
The price is MXN$1,391 per night from Nov 5 to Nov 6
MXN$1,391
MXN$1,544 total
5 Nov - 6 Nov
includes taxes & fees
7.8/10 Good! (1,376 reviews)
Spotless and comfy.

Reviewed on 29 Oct 2025

Baymont by Wyndham Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St., Santee, SC
Fully refundableReserve now, pay when you stay
The price is MXN$2,059 per night from Nov 16 to Nov 17
MXN$2,059
MXN$2,286 total
16 Nov - 17 Nov
includes taxes & fees
9/10 Wonderful! (581 reviews)
Easy off/on I-95, staff very nicely accommodated my request to refreeze some ice packs I had to keep medicine cold while traveling and quickly retrieved ice packs for me in morning, staff very friendly and efficient. Room was nice and well stocked with towels soaps etc and bed very clean

Reviewed on 29 Oct 2025

Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

2.5 out of 5
9074 Old Number Six Hwy, Santee, SC
Fully refundableReserve now, pay when you stay
The price is MXN$2,245 per night from Dec 1 to Dec 2
MXN$2,245
MXN$2,491 total
1 Dec - 2 Dec
includes taxes & fees
9.8/10 Exceptional! (1,003 reviews)
Our room was very clean and the main desk folks were wonderful!

Reviewed on 31 Oct 2025

Fairfield Inn & Suites by Marriott Santee
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.